NS201A: Basic Concepts in Cellular and Molecular Neuroscience

An interdisciplinary introduction to fundamental aspects of nervous system function. The course emphasizes the ionic and molecular basis of excitability, synaptic transmission and signal transduction.

Directors: Peter Sargent and Jennifer Whistler

NS201A Outline

General Reading List for NS201A

Past Exams

2013 Exam
2013 Exam Key
(Note: in 2013 there was one exam for the six week long course)

2014 First Exam
2014 First Exam Key

2015 First Exam
(no key available)

First Block - Electrophysiology (Sargent)

General Reading List for 1st Block

Thursday, September 22
Time: 9AM-11AM, GH-S261
Topic: Membrane Potential
Instructor: Peter Sargent

Friday, September 23
Time: 9AM-11AM, GH-S261
Topic: Action Potentials
Instructor: Peter Sargent

Monday, September 26
Time: 9AM-11AM, GH-S261
Topic: Single Channels
Instructor: Peter Sargent

Tuesday, September 27
Time: 8AM-11AM, GH-S261
Topic: Biophysics Problem Set
Instructor: Peter Sargent

2nd Block - Ion Channel Structure (Kirickok, Jan)

Reading Materials for Kiricok

Thursday, September 29
Time: 9AM-11AM, GH-S261
Topic: Structure-Function 1
Instructor: Yuriy Kirichok

Friday, September 30
Time: 9AM-11AM, BH-209
Topic: Structure-Function 2
Instructor: Yuriy Kirichok

Thursday, October 6
Time: 9AM-12PM, GH-S261
Topic:Potassium Channels
Paper Discussion 1: NavAbNature2011; Supplemental
Paper Disccusion 2: CavAbNature2013; Supplemental
Instructor: Lily Jan

3rd Block - Synaptic Transmission (Sargent)

General Reading List for 3rd Block

Binomial

Friday, October 7
Time: 9AM-11AM, BH-209
Topic: Synaptic Transmission 1
Instructor: Peter Sargent

Monday, October 10
Time: 9AM-11AM, GH-S261
Topic: Synaptic Transmission 2
Instructor: Peter Sargent

Thursday, October 13
Time: 9AM-12PM, GH-S261
Topic: Synaptic Transmission Problem Set & Paper Discussion
Instructor: Peter Sargent

4th Block - Integration (Bender)

Reading List and Discussion Points for 4th Block

Friday, October 14
Time: 9AM-11AM, BH-209
Topic: Integration 1
Instructor: Kevin Bender

Monday, October 17
Time: 9AM-12PM, GH-S261
IN-CLASS EXAM 1

Tuesday, October 18
Time: 9AM-11AM, GH-S261
Topic: Integration 2
Instructor: Kevin Bender

Thursday, October 20
Time: 9AM-12PM, GH-S261
Topic: Integration Paper Discussions
Paper Discussion 1: Shepherd v3 Appendix
Paper Discussion 2: Silver-Neuronal Arithmetic
Paper Discussion 3: Poleg-Polsky and Diamond 2016
Instructor: Kevin Bender

5th Block - Glutamate Receptors and Plasticity (Nicoll)

Friday, October 21
Time: 9AM-11AM, BH-209
Topic: Glutamate Receptors
Instructor: Roger Nicoll

Monday, October 24
Time: 9AM-11AM, GH-261
Topic: Plasticity
Instructor: Roger Nicoll

Tuesday, October 25
Time: 9AM-12PM, GH-S261
Topic: Plasticity Paper Discussion
Instructor: Roger Nicoll

6th Block - Neurotransmitter Release and Re-uptake (Edwards)

Book Chapters Review
Calcium Control of Neurotransmitter Release 
Vesicular and Plasma Membrane Transporters for Neurotransmitters
Short-Term Presynaptic Plasticity
Synaptic Vesicle Endocytosis
Synaptic Vesicle Exocytosis
Synaptic Vesicle Pools and Dynamics

Thursday, October 27
Time: 9AM-11AM, GH-S261
Topic: Neurotransmitter Release
Instructor: Robert Edwards

Friday, October 28
Time: 9AM-11AM, BH-209
Topic: Neurotransmitter Reuptake
Instructor: Robert Edwards

Monday, October 31
Time: 9AM-12PM, GH-S261
Topic: Release/Reuptake Paper Discussion
Paper Discussion
Instructor: Robert Edwards

7th Block - Receptor Pharmacology (Whistler)

Background materials
Colquhoun
Kenakin
Strange

Tuesday, November 1
Time: 10AM-12PM, GH-S261
Topic: Receptor Pharmacology 1
Instructor: Jennifer Whistler

Thursday, November 3
Time: 9AM-11AM, GH-S261
Topic: Receptor Pharmacology 2
Instructor: Jennifer Whistler

Friday, November 4
Time: 9AM-12PM, BH-209
Topic: Receptor Pharmacology Paper Discussion
Assigned Paper - Fribourg with Supplement
Table Fribourg Partial
Background Reading for Paper
Study Questions
Problem Set
Instructor: Jennifer Whistler

Friday, November 4
Time: 12PM-1PM, BH-209
Live Course Evaluation led by Su Guo

Monday, November 7
Time: 9AM-12PM, GH-S261
IN-CLASS EXAM 2