Course Description: We will cover a broad range of neurobiological findings from individuals with schizophrenia and animal models of schizophrenia in order to critically evaluate potential pathophysiological mechanisms. Topics will include: microglia, neuronal oscillations, neurophysiology, imaging, genetics, optogenetics, and rodent behavioral assays.
Course Directors: Vikaas Sohal and Judith Ford
For your study list please use:
NS 219, 3 units, Director: Vikaas Sohal, Grade option: S/U
Course Schedule:
Monday, April 24
Time: 9AM-11AM, MH-2106
Topic: Clinical Phenomenology, Prodrome, and Biomarkers
Instructor: Demian Rose & Dan Mathalon
https://www.dropbox.com/s/k42417lizcc0thg/Evidence%20Based%20Remission%20in%20SCZ.pdf?dl=0
https://www.dropbox.com/s/bkea3dxif71awm7/Stability%20of%20DSM%20IV%20Psychosis%20Diagnoses.pdf?dl=0
LEAD DISCUSSION:
Tuesday, April 25
Time: 9AM-11AM
Topic: Functional Connectivity / fMRI
Instructor: Susanna Fryer
PAPERS TO DISCUSS:
Bucker, Neuroimage, 2012
http://www.sciencedirect.com/science/article/pii/S1053811911011992
Biswal et al., Magnetic Resonance Res, 1995
https://www.dropbox.com/s/3ge49xbzii2svw7/biswal_fconn_1995.pdf?dl=0LEAD DISCUSSION:
Wednesday, April 26
Time: 9AM-11AM, MH-2106
Topic: Oxytocin and Social Behavior
Instructor: Josh Woolley
FOR BACKGROUND:
https://www.dropbox.com/s/b3p4rxfr4ri9unw/Social%20cognition%20in%20schizophrenia.pdf?dl=0
FOR DISCUSSION:
https://www.dropbox.com/s/36pq2s5to7yprmt/feith-oxytocin.pdf?dl=0
https://www.dropbox.com/s/t3v9axq96ytekkf/woolley-oxytocin.pdf?dl=0
LEAD DISCUSSION: Rose
Thursday, April 27
Time: 9AM-11AM
Topic: Hallucinations & Corollary Discharge
Instructor: Judy Ford
PAPERS TO DISCUSS:
Alderson-Day, Schizophrenia Bulletin, 2016
https://academic.oup.com/schizophreniabulletin/article-lookup/doi/10.1093/schbul/sbw078
Rummel et al., J Neurosci, 2016
http://www.jneurosci.org/content/36/47/12010.long
Oertel-Knöchel V et al., Schizophrenia Bulletin, 2014
https://www.ncbi.nlm.nih.gov/pubmed/25464916
Diederen et al., Am J Psych, 2010
http://ajp.psychiatryonline.org/doi/abs/10.1176/appi.ajp.2009.09040456?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed
LEAD DISCUSSION:
Friday, April 28
Time: 9AM-11AM, MH-2106
Topic: Gamma Oscillations
Instructor: Vikaas Sohal
BACKGROUND READING / REVIEWS:
Gonzalez-Burgos et al., Biological Psychiatry, 2015
http://www.sciencedirect.com/science/article/pii/S0006322315002243
Senkowski and Gallinat, Biological Psychiatry, 2015
http://ac.els-cdn.com/S0006322315001602/1-s2.0-S0006322315001602-main.pdf?_tid=6196ffd2-251d-11e7-981c-00000aab0f27&acdnat=1492619558_e39d270cac0ef1506b9409a1d66370d1
FOR DISCUSSION:
Sigurdsson et al., Nature, 2010
https://www.nature.com/nature/journal/v464/n7289/pdf/nature08855.pdf
Tamura et al., Neuron, 2016
http://www.sciencedirect.com/science/article/pii/S0896627316000507
Cho et al., Neuron, 2015
http://ac.els-cdn.com/S0896627315001348/1-s2.0-S0896627315001348-main.pdf?_tid=f2c74864-251c-11e7-a1e2-00000aacb35f&acdnat=1492619372_5b8f734678d4315bd8403d6ee02196a3
OPTIONAL FURTHER READING:
Mukai et al., Neuron, 2015
http://ac.els-cdn.com/S0896627315003323/1-s2.0-S0896627315003323-main.pdf?_tid=ad556126-251c-11e7-ba48-00000aacb362&acdnat=1492619255_8fd35447f70c8cd7f1e92060a8c4041e
Canetta et al., Mol Psych, 2016
https://www.nature.com/mp/journal/v21/n7/pdf/mp2015222a.pdf
LEAD DISCUSSION: Jiggy
Monday, May 1
Time: 9AM-11AM, MH-2106
Topic: Interneuron Development
Instructor: John Rubenstein
BACKGROUND READING:
Marin et al., Nat Rev Neurosci, 2012
https://www.dropbox.com/sh/5tkl89306poaame/AABhaZuo1RG4uU_6cTnqRIBua?dl=0&preview=marin+review.pdf
PAPERS TO DISCUSS
Hu et al. (Rubenstein lab)
https://www.dropbox.com/sh/5tkl89306poaame/AABhaZuo1RG4uU_6cTnqRIBua?dl=0&preview=DEVELOP-2015-132852v1-Vogt-1+copy.pdf
Volk et al., Schizophrenia Bulletin
https://www.dropbox.com/sh/5tkl89306poaame/AABhaZuo1RG4uU_6cTnqRIBua?dl=0&preview=volk+and+lewis+2016.pdf
LEAD DISCUSSION: Carmen
Tuesday, May 2
Time: 9AM-11AM,
Topic: Thalamocortical dysconnectivity, Volume Loss, & Dopamine Imaging
Instructor: Vikaas Sohal & Dan Mathalon
BACKGROUND READING / REVIEWS:
Minzenberg and Carter, TiCS, 2012
http://ac.els-cdn.com/S1364661311002506/1-s2.0-S1364661311002506-main.pdf?_tid=b06192a8-251d-11e7-bea6-00000aacb362&acdnat=1492619690_51ca105bdcaa27b5ca44d26e4c8ef2bf
Weinstein et al., Biol Psych, 2017
http://ac.els-cdn.com/S0006322316322375/1-s2.0-S0006322316322375-main.pdf?_tid=f6287008-251e-11e7-ad26-00000aacb362&acdnat=1492620236_104cd2186300fa2be13548f66cf0c0d1
FOR DISCUSSION:
Cannon et al., Biol Psych, 2014
http://ac.els-cdn.com/S0006322314004144/1-s2.0-S0006322314004144-main.pdf?_tid=7bcca91e-251e-11e7-b48b-00000aab0f26&acdnat=1492620031_0fdc5b813f242b52b699d4320b8421b5
Anticevic et al., JAMA Psych, 2015
http://jamanetwork.com/journals/jamapsychiatry/fullarticle/2426421
Silfstein et al., JAMA Psych, 2017
http://jamanetwork.com/journals/jamapsychiatry/fullarticle/2108652
LEAD DISCUSSION: Nick Woods
Wednesday, May 3
Time: 9AM-11AM, MH-2106
Topic: Genetics
Instructor: Stephan Sanders
BACKGROUND READING:
De novo exome analysis: https://www.dropbox.com/s/yjcdn4tuygkk1b6/De%20novo%20mutations%20in%20schizophrenia%20implicate%20synaptic%20networks%202014.pdf?dl=0
Rare variant exome analysis: https://www.dropbox.com/s/tapdff6y9rrbdtb/A%20polygenic%20burden%20of%20rare%20disruptive%20mutations%20in%20schizophrenia%202014.pdf?dl=0
Recessive exome analysis: https://www.dropbox.com/s/hdt7102ls1ukzon/Analysis%20of%20exome%20sequence%20in%20604%20trios%20for%20recessive%20genotypes%20in%20schizophrenia%202015.pdf?dl=0
FOR DISCUSSION:
1) Ripke 108 common loci:
https://www.dropbox.com/s/r451xe4yme4jiw0/Biological%20insights%20from%20108%20schizophrenia-associated%20genetic%20loci%202014.pdf?dl=0
2) Marshall 8 rare CNV loci: https://www.dropbox.com/s/xnrbnfcuzfhvpaf/A%20contribution%20of%20novel%20CNVs%20to%20schizophrenia%20from%20a%20genome-wide%20study%20of%2041%2C321%20subjects%202016.pdf?dl=0
3) Fromer post mortem SCH brain: https://www.dropbox.com/s/1d5d0cvc7scord7/Gene%20expression%20elucidates%20functional%20impact%20of%20polygenic%20risk%20for%20schizophrenia%202016.pdf?dl=0
LEAD DISCUSSION: Adrienne Thom
Thursday, May 4
Time: 9AM-11AM, MH-2106
Topic: Dopamine, Etc.
Instructor: Vikaas Sohal
BACKGROUND READING:
Moghaddam and Krystal, Schiz Bull, 2012
https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/schizophreniabulletin/38/5/10.1093/schbul/sbs075/2/sbs075.pdf?Expires=1492966092&Signature=JxfvjKV3sSUEJ02Vp1JDtlidH7AhgwW3WYpjkn5225Pi3f3c3zOCQxoswkPRf1SbeTr5m7oT1sed8DjlkhIkJnWiDyVUExwcOGbIFM40w8tB~Bir2A1yzl8KQNsC~1oCNWhjuwaigNta7tLgEQWqdg3Sjm-hfscjyZNToI9VJyJd5iD~Brr4C32dDrgbyTuCiMXVXejXSAAQtpfWhM-fhMgD8G5nlFJ69S5hU3bSwQTxGtVwwWiVRJGg0i02WM-DJ2VQRjIh1SkEumLU4zTIMjy6kjfOdipGfGtTMbRYV-Bu~Zmbakx1L7rGX5NAN6niROt0UxMzhDyDFPig5IKZZQ__&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q
FOR DISCUSSION:
Kellendonk et al., Neuron, 2006
http://www.sciencedirect.com/science/article/pii/S0896627306000778
Chun et al., Science, 2014
http://science.sciencemag.org/content/344/6188/1178/tab-pdf
Hamm et al., Neuron, 2017
http://ac.els-cdn.com/S0896627317302027/1-s2.0-S0896627317302027-main.pdf?_tid=4ade0fac-2521-11e7-a449-00000aacb361&acdnat=1492621237_aa2ac2bed70b2ecb4906da52e353802e
Lead Discussion: Alex Clemente
Friday, May 5
Time: 9AM-11AM, MH-2106
Topic: Microglia & Neuroimmunology
Instructor: Anna Molofsky
Background review:
https://www.dropbox.com/s/9nzd98ekdnw5ie8/796964E4-F030-421B-BFD0-7DC476423B1E.pdf?dl=0
Primary article for discussion:
https://www.dropbox.com/s/tzjb1y8ikm6u8f2/A5A7969C-87E4-482B-8E98-AAFF009C7873.pdf?dl=0
Lead Discussion: Meryl Horn