Daniel Minor, PhD

Professor
Cardiovascular Research Institute
415-514-2551

Structural and Mechanistic Studies of Ion Channels and Ion Channel Regulation

Ion channel proteins control the passage of ions across the cell membrane and generate the bioelectricity that is essential for life.  Much of the future of neuroscience and cardiovascular research lies in understanding the molecular details of how these protein machines function, how they are regulated, and how they are integrated into large, macromolecular complexes within the cell.  To address these issues, our lab seeks to uncover the basic mechanisms by which ion channels act.  This ultimately requires a high-resolution structural description of the channel proteins, their regulatory factors, and the conformational changes that accompany channel action as well as the development of means to manipulate channel action in vivo.

Current Projects

Ion channel proteins control the passage of ions across the cell membrane and generate the bioelectricity that is essential for life.  Much of the future of neuroscience and cardiovascular research lies in understanding the molecular details of how these protein machines function, how they are regulated, and how they are integrated into large, macromolecular complexes within the cell.  To address these issues, our lab seeks to uncover the basic mechanisms by which ion channels act.  This ultimately requires a high-resolution structural description of the channel proteins, their regulatory factors, and the conformational changes that accompany channel action as well as the development of means to manipulate channel action in vivo

  1. Structural understanding of ion channel action and regulation
  2. Molecular evolution of ion channel modulators for channels
  3. Membrane proteins expression and structure

Lab Members

Fayal Abderemane Ali, PhD
Postdoctoral Fellow
fayal.abderemaneali@ucsf.edu

Aram Chang, PhD
Postdoctoral Fellow
aram.chang@ucsf.edu

Christopher Kimberlin, PhD
Postdoctoral Fellow
christopher.kimberlin@ucsf.edu

Christina Arrigoni, PhD
Postdoctoral Fellow
christina.arrigoni@ucsf.edu

Marco Lolicato, PhD
Postdoctoral Fellow
marco.lolicato@ucsf.edu

Kim Clark 
Research Specialist
kimberly.clark@ucsf.edu

Lianne Pope
Graduate Student
lianne.devera@ucsf.edu

Lab Website

Publications: