People

Katerina Akassoglou, PhD

Senior Investigator
Neurology

Neurovascular Mechanisms of Inflammation and Tissue Repair

Our lab studies mechanisms of neurovascular regulation of inflammation and tissue repair. Our current research focuses on identifying the molecular and cellular interface that blood proteins utilize to interact with nervous system cells and change their functions. Our ultimate goal is to target these interactions for therapeutic intervention in neurologic diseases.

Arturo Alvarez-Buylla

Professor
Neurological Surgery

Birth and Migration of New Neurons 

Our laboratory studies the mechanisms of adult neurogenesis and neuronal replacement.  Contrary to the dogma held for over a century, some populations of neurons continue to be produced in juvenile and adult brains.  Basic mechanisms of neural development can be studied in a fully assembled brain, providing key insights into the nature of neural stem cells, mechanisms of neuronal migration, and neural maturation.

Our goals are to understand:

1) How young neurons are generated.

Kaveh Ashrafi, PhD

Associate Professor
Physiology

Analysis of Genetic and Neuronal Networks that Regulate Fat Content

Scott Baraban, PhD

Professor
Neurological Surgery

Neurobiology of Epilepsy

Nearly 3 million Americans suffer from epilepsy. In one third of these patients available antiepileptic drugs or invasive surgical procedures are not effective. With an increased understanding of the molecular, electrophysiological and genetic bases of the epilepsies, hope for a cure emerges.  Understanding the fundamental basis of epilepsies, especially those that occur in children, and using this information to develop novel treatments is the mission of our laboratory.

Samuel Barondes, MD

Professor Emeritus
Psychiatry

Biological Psychiatry

Allan Basbaum, PhD

Professor & Chair
Anatomy

The Neurobiological Basis of Pain and Its Control

Kevin Bender, PhD

Assistant Professor
Neurology

Mechanisms and Function of Neuromodulation

Neurons are finely tuned to extract computationally relevant features from synaptic inputs. This process is influenced heavily by neuromodulators, which can transiently retune neuronal processing by altering the properties of the membrane receptors and channels involved in synaptic transmission and cell excitability. Drugs of abuse disrupt neuromodulator signaling, ultimately producing long-lasting changes in the neuronal circuits that underlie addiction establishment, expression, and relapse.

Joshua Berke, PhD

Professor
Neurology

Neurobiology of Motivation and Adaptive Decision-Making

Michael Brainard, PhD

Professor
Physiology

Sensorimotor Learning in the Song System

Research in my laboratory focuses primarily on the question of how experience, particularly during early life, shapes the functioning of the nervous system. To approach this question we are currently using a combination of behavioral and neurophysiological techniques to investigate the mechanisms underlying vocal learning in songbirds.

Jonah Chan, PhD

Professor
Neurology

Neuronal/Glial Interactions that Control Myelination

Edward Chang, MD

Professor
Neurological Surgery

Speech Mechanisms

A unique and defining trait of human behavior is our ability to communicate through speech. My laboratory is interested in determining the basic mechanisms that underlie speech perception and production.  While much of this processing has been localized to the peri-sylvian cortex, including Broca’s and Wernicke’s areas, the fundamental organizational principles of these neural circuits are completely unknown.

Ben Cheyette, MD PHD

Associate Professor
Psychiatry

Signaling Scaffold Proteins in Development and Major Psychiatric Disorders

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