Roger Nicoll, MD

Cellular and Molecular Pharmacology

The Cellular and Molecular Basis of Synaptic Plasticity

My lab is interested in elucidating the cellular and molecular mechanisms underlying learning and memory in the mammalian brain. Long-term potentiation (LTP), a phenomenon in which brief repetitive activity causes a long lasting (many weeks) enhancement in the strength of synaptic transmission, is generally accepted to be a key cellular substrate for learning and memory. My lab uses a combination of electrophysiological and molecular techniques to elucidate the molecular basis of LTP. We have found that LTP involves the rapid activity-dependent trafficking of glutamate receptors to the synapse. This trafficking requires the interaction of two families of synaptic proteins. One family is a novel group of proteins that, we discovered which bind to glutamate receptors and act as auxiliary subunits. These proteins are not only essential for the trafficking of the glutamate receptors, but also control the gating of the receptor channel. The other family is comprised of a family of scaffolding proteins that bind to the auxiliary subunits and thereby anchor the receptors at the synapse. Much of the current work in the lab is focused on how activity controls this receptor trafficking and how the increase in synaptic strength during LTP is stabilized and maintained.

Current Projects

  1. AMPA receptor subunits in receptor trafficking
  2. MAGUK scaffolding proteins in anchoring synaptic AMPA receptors
  3. Conditional knock out mice to explore the role of synaptic proteins in glutamate receptor trafficking
  4. TARPs control of AMPA receptor gating
  5. Activity dependent trafficking of NMDA receptors

Lab Members

Salvatore Incontro, PhD
Postdoctoral Fellow

Argentina Lario Lago, PhD
Postdoctoral Fellow

Javi Diaz Alonso, PhD
Postdoctoral Fellow

Wucheng Tao, PhD
Postdoctoral Fellow

Nengyin Sheng, PhD
Postdoctoral Fellow

Quynh-Anh Nguyen
Neuroscience Graduate Student

Meryl Horn
Neuroscience Graduate Student

Dan Qin
Research Associate

Lab Website