Jonah Chan, PhD

Professor
Neurology
415-514-9818

Neuronal/Glial Interactions that Control Myelination

Neurons and glia share a mutual dependence in establishing a functional relationship that is controlled by the integration of complex molecular signals and pathways. These reciprocal interactions control multiple cellular processes, including survival, proliferation, migration, cell-fate determination, and differentiation. The formation of myelin is an exquisite and dynamic example of cell-cell interaction that involves the myelin-forming cell and the neuron. The myelin sheath is responsible for the rapid propagation of the action potential, which is functionally essential for the long-distance communication in the nervous system. My research interests are to understand these fundamental glial/neuronal interactions and the molecular mechanisms that regulate myelination. More importantly, the implications of my research relate specifically to the identification of new target molecules and signaling pathways in the development of potential therapeutics for demyelinating diseases. Recent findings and technical advances with both PNS and CNS glia provide a rare opportunity to characterize these target molecules and signaling pathways.

Lab Members

Trung Huynh, BS
Lab Manager
[email protected]

Kae-Jiun Chang, PhD
Postdoctoral Fellow
[email protected]

Sarah Raissi, PhD
Postdoctoral Fellow
[email protected]

Maggie Yeung, PhD
Postdoctoral Fellow
[email protected]

Wendy Xin, PhD
Postdoctoral Fellow
[email protected]

Monique Lillis, BS
Graduate Student
[email protected]

Albert Zhang, PhD
Postdoctoral Fellow
[email protected]

Sonia Nocera, PhD
Postdoctoral Fellow
[email protected]

Websites

Chan Lab
Biomedical Sciences Graduate Program

Featured Publications: