Alzheimer's & Dementia

Reversal of C9orf72 mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision.

KLOTHO KL-VS genotype modifies the relationship between cardiorespiratory fitness and CSF biomarkers of neurodegeneration, synaptic dysfunction, and inflammation.

Uncovering mechanisms of hyperexcitability in tauopathies with functional genomics.

Exploring selective neuronal vulnerability in Alzheimer’s disease – key pathways are downregulated in vulnerable subpopulations of RORB and CDH9 excitatory neurons of the entorhinal cortex at Braak 0.

Systemic Mechanisms of Brain Aging and Rejuvenation.

KLOTHO KL-VS heterozygosity is associated with diminished age-related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adults.

Predictive Modeling Leveraging Electronic Health Records Identifies Early Predictors of Alzheimer’s Disease.

Plasma rejuvenation factor GDF11 associates with amyloid-related cognitive decline in older adults across the Alzheimer’s Disease spectrum.

Phospholipase D3 drives microglial response to amyloid pathology in Alzheimer’s disease.

Multiomics of iPSC-derived ApoE3- and ApoE4 astrocytes and microglia uncovers cell type specific dysregulation of immunometabolism.

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