Date:
November 10, 2021
Time:
3:00 pm
Abstract: The brain vasculature is of vast medical importance: its dysfunction causes disability and death, and the specialized structure it forms—the blood-brain barrier (BBB)—impedes treatment of nearly all brain disorders. Here, we will present a first single-cell atlas of the human brain vasculature, define its organizational principles, and reveal its links to Alzheimer’s disease. We will then share our progress developing proteome labeling techniques to decipher unexpected communication across the BBB. Our ultimate goal is to decode the diverse mechanisms by which the BBB maintains brain homeostasis, and we are excited to join the UCSF Neuroscience community.