Martin Kampmann, PhD

Associate Professor
M_Biochemistry and Biophysics
+1 415 514-5545

Functional genomics to understand molecular mechanisms of brain function and disease

Research Description

The Kampmann lab develops and applies innovative technologies to understand cellular and molecular
mechanisms of human brain diseases, and to discover new therapeutic strategies. We have pioneered
a CRISPR-based functional genomics platform in human iPSC-derived neurons, glia and 3D
assembloids, which enables genome-wide modifier screens of disease-relevant cell biology in patient-derived cells. We use biochemistry, biophysics and cell biology to test mechanistic hypotheses
generated by our functional genomics platform.

 
Current Projects

We have many possible projects addressing our major research questions:

• What are the mechanisms by which disease-associated genetic variants cause brain diseases?

• What controls protein aggregation in neurons, and why is it toxic?

• How is dysfunction of different cellular processes (neuronal activity, protein homeostasis,
autophagy, endolysosomal trafficking, mitochondria) coupled in neurodegeneration?

• Which molecular mechanisms underlie the selective vulnerability of specific subtypes of neurons
to stress and disease?

• What controls beneficial and toxic functions of astrocytes and microglia in disease?

In addition, we have projects in technology development and computation
• In-vivo CRISPR screening

• High-content / multi-modality screening

• Machine learning to understand mapping between different high-dimensional phenotypes (e.g. neuronal activity, transcriptomics, morphology)


Lastly, we always welcome new students and postdocs to propose their own ideas for projects.

Lab Members

Nabeela Ariqat (Staff Research Associate)
Giovanni Aviles (Staff Research Associate)
Steven Boggess, PhD (Postdoc)
Merissa Chen (Staff Research Associate)
Brandon Desousa (Graduate student, joint with Jain lab)
Gary Dixon, PhD (Postdoc)
Nina Dräger, PhD (Postdoc)
Vaidehi Gandhi (Staff Research Associate)

Parker Grosjean (Graduate student, joint with Keiser lab)
Xiaoyan Guo, PhD (Postdoc)
Martin Kampmann (PI)
Sarah Kaufman, MD PhD (Neurology Resident/Postdoc)
Lydia Lee (Lab assistant)
Jaime Leong (Lab manager)
Emmy Li (Graduate student)
Amanda McQuade (Postdoc)
Greg Mohl (Graduate student)

Andrew Pan (Staff Research Associate)
Gokul Ramadoss (Graduate student, joint with Conklin lab)
Biswa Ramani, MD, PhD (Postdoc)
Indigo Rose (Graduate student)
Avi Samelson, PhD (Postdoc)
Olivia Teter (Graduate student)
Noam Teyssier (Graduate student, joint with Goodarzi lab)
Lin Yadanar (Lab assistant, joint with Mordes lab)

Lab Website

 

Academic community service and committee membership:

Faculty Search Committee, Department of Cellular & Molecular Pharmacology, Co-chair, Admissions Committee, UCSF Tetrad Graduate Program, BBC Graduate Programs Seminar Committee, Biophysics Program Diversity, Equity and Inclusion Working Group, Biophysics Program Award Committee, Faculty Advisor to the UCSF Graduate & Postdoc Queer Alliance

Publications

Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.

M_Anatomy-General

Parra Bravo C, Giani AM, Perez JM, Zhao Z, Wan Y, Samelson AJ, Wong MY, Evangelisti A, Cordes E, Fan L, Ye P, Zhu D, Pozner T, Mercedes M, Patel T, Yarahmady A, Carling GK, Sterky FH, Lee VMY, Lee EB, DeTure M, Dickson DW, Sharma M, Mok SA, Luo W, Zhao M, Kampmann M, Gong S, Gan L

International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis.

Chen X, Tsvetkov AS, Shen HM, Isidoro C, Ktistakis NT, Linkermann A, Koopman WJH, Simon HU, Galluzzi L, Luo S, Xu D, Gu W, Peulen O, Cai Q, Rubinsztein DC, Chi JT, Zhang DD, Li C, Toyokuni S, Liu J, Roh JL, Dai E, Juhasz G, Liu W, Zhang J, Yang M, Liu J, Zhu LQ, Zou W, Piacentini M, Ding WX, Yue Z, Xie Y, Petersen M, Gewirtz DA, Mandell MA, Chu CT, Sinha D, Eftekharpour E, Zhivotovsky B, Besteiro S, Gabrilovich DI, Kim DH, Kagan VE, Bayir H, Chen GC, Ayton S, Lünemann JD, Komatsu M, Krautwald S, Loos B, Baehrecke EH, Wang J, Lane JD, Sadoshima J, Yang WS, Gao M, Münz C, Thumm M, Kampmann M, Yu D, Lipinski MM, Jones JW, Jiang X, Zeh HJ, Kang R, Klionsky DJ, Kroemer G, Tang D

Phospholipase D3 drives microglial response to amyloid pathology in Alzheimer’s disease.

Matthew J Rosene, Emma Danhash, Shih-Feng You, Abhirami Kannan Iyer, Simon Hsu, Mariana Acquarone de Sa Lopes, Logan Brase, Anthony Verbeck, Rita Martinez, Clare E Wallace, Zeran Li, Ping Yan, Nina Drager, Sydney M Sattler, Thomas E Mahan, Shannon L Macauley, David M. Holtzman, Bruno A. Benitez, Martin Kampmann, Carlos Cruchaga, Oscar Harari, John R Cirrito, Jin-Moo Lee, Alison Goate, Celeste M. Karch

A reference human induced pluripotent stem cell line for large-scale collaborative studies.

Pantazis CB, Yang A, Lara E, McDonough JA, Blauwendraat C, Peng L, Oguro H, Kanaujiya J, Zou J, Sebesta D, Pratt G, Cross E, Blockwick J, Buxton P, Kinner-Bibeau L, Medura C, Tompkins C, Hughes S, Santiana M, Faghri F, Nalls MA, Vitale D, Ballard S, Qi YA, Ramos DM, Anderson KM, Stadler J, Narayan P, Papademetriou J, Reilly L, Nelson MP, Aggarwal S, Rosen LU, Kirwan P, Pisupati V, Coon SL, Scholz SW, Priebe T, ?ttl M, Dong J, Meijer M, Janssen LJM, Lourenco VS, van der Kant R, Crusius D, Paquet D, Raulin AC, Bu G, Held A, Wainger BJ, Gabriele RMC, Casey JM, Wray S, Abu-Bonsrah D, Parish CL, Beccari MS, Cleveland DW, Li E, Rose IVL, Kampmann M, Calatayud Aristoy C, Verstreken P, Heinrich L, Chen MY, Sch?le B, Dou D, Holzbaur ELF, Zanellati MC, Basundra R, Deshmukh M, Cohen S, Khanna R, Raman M, Nevin ZS, Matia M, Van Lent J, Timmerman V, Conklin BR, Johnson Chase K, Zhang K, Funes S, Bosco DA, Erlebach L, Welzer M, Kronenberg-Versteeg D, Lyu G, Arenas E, Coccia E, Sarrafha L, Ahfeldt T, Marioni JC, Skarnes WC, Cookson MR, Ward ME, Merkle FT

Robust Sequence Determinants of a-Synuclein Toxicity in Yeast Implicate Membrane Binding.

Newberry RW, Arhar T, Costello J, Hartoularos GC, Maxwell AM, Naing ZZC, Pittman M, Reddy NR, Schwarz DMC, Wassarman DR, Wu TS, Barrero D, Caggiano C, Catching A, Cavazos TB, Estes LS, Faust B, Fink EA, Goldman MA, Gomez YK, Gordon MG, Gunsalus LM, Hoppe N, Jaime-Garza M, Johnson MC, Jones MG, Kung AF, Lopez KE, Lumpe J, Martyn C, McCarthy EE, Miller-Vedam LE, Navarro EJ, Palar A, Pellegrino J, Saylor W, Stephens CA, Strickland J, Torosyan H, Wankowicz SA, Wong DR, Wong G, Redding S, Chow ED, DeGrado WF, Kampmann M

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity.

eLife

Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, Lin WL, Tong J, Daughrity LM, Yue M, Song Y, Andersen JW, Castanedes-Casey M, Kurti A, Datta A, Antognetti G, McCampbell A, Rademakers R, Oskarsson B, Dickson DW, Kampmann M, Ward ME, Fryer JD, Link CD, Shorter J, Petrucelli L

The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.

M_Anatomy-General

Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ

Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance.

Mavor D, Barlow KA, Asarnow D, Birman Y, Britain D, Chen W, Green EM, Kenner LR, Mensa B, Morinishi LS, Nelson CA, Poss EM, Suresh P, Tian R, Arhar T, Ary BE, Bauer DP, Bergman ID, Brunetti RM, Chio CM, Dai SA, Dickinson MS, Elledge SK, Helsell CVM, Hendel NL, Kang E, Kern N, Khoroshkin MS, Kirkemo LL, Lewis GR, Lou K, Marin WM, Maxwell AM, McTigue PF, Myers-Turnbull D, Nagy TL, Natale AM, Oltion K, Pourmal S, Reder GK, Rettko NJ, Rohweder PJ, Schwarz DMC, Tan SK, Thomas PV, Tibble RW, Town JP, Tsai MK, Ugur FS, Wassarman DR, Wolff AM, Wu TS, Bogdanoff D, Li J, Thorn KS, O'Conchúir S, Swaney DL, Chow ED, Madhani HD, Redding S, Bolon DN, Kortemme T, DeRisi JL, Kampmann M, Fraser JS

Body fluid identification using a targeted mRNA massively parallel sequencing approach - results of a EUROFORGEN/EDNAP collaborative exercise.

Nature Neuroscience

Ingold S, Dørum G, Hanson E, Berti A, Branicki W, Brito P, Elsmore P, Gettings KB, Giangasparo F, Gross TE, Hansen S, Hanssen EN, Kampmann ML, Kayser M, Laurent FX, Morling N, Mosquera-Miguel A, Parson W, Phillips C, Porto MJ, Pospiech E, Roeder AD, Schneider PM, Schulze Johann K, Steffen CR, Syndercombe-Court D, Trautmann M, van den Berge M, van der Gaag KJ, Vannier J, Verdoliva V, Vidaki A, Xavier C, Ballantyne J, Haas C

The mTOR Complex Controls HIV Latency.

Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E