Michael Stryker, PhD

Professor

Physiology

[email protected]

415-502-7380

Development and Plasticity of the Central Visual System

Our laboratory's major interest is the in the mechanisms responsible for the development and plasticity of precise connections within the central nervous system, and particularly in the role of neural activity in this process. Most of the work of the laboratory is on the visual cortex of the mouse. In normal development, neural connections to and within the visual cortex are refined to high precision through the action of activity-dependent mechanisms of neural plasticity in combination with specific molecular signals. In our experiments, we induce activity-dependent plasticity experimentally through manipulations of genetics or experience or by pharmacological or neurophysiological intervention in order to discover what cellular mechanisms and what changes in cortical circuitry are responsible for rapid, long lasting changes in neuronal responses. We analyze these changes using microelectrode recordings, novel techniques for measurement of optical and metabolic signals related to neural activity, including 2-photon microscopy and intrinsic signal imaging, and anatomical and neurochemical tracing of connections.

Current experimental work in the laboratory focuses on four areas: (a) Understanding the coupling between the physiological and anatomical changes responsible for neuronal plasticity. (b) Understanding the cellular mechanisms of activity-dependent cortical plasticity, primarily through the use of transgenic mice. (c) Understanding the interaction between neural activity and molecular cues in the formation of cortical maps. (d) Understanding the difference between the limited plasticity in the adult brain and the much greater plasticity during critical periods in early life.

Lab Members

Megumi Kaneko
Postdoctoral Fellow
[email protected]

Maria Dadarlat
Postdoctoral Fellow
[email protected]

Yujiao Sun
Postdoctoral Fellow
[email protected]

Nikhil Bhatla
Postdoctoral Fellow
[email protected]

Anna Lebedeva
Graduate Visitor
[email protected]

Umais Khan
Junior Specialist
[email protected]

Lab Website

Academic community service and committee membership:

Former program head; current Academic Senate Research Allocation (RAP) reviewer; Board of Directors and SAB, Allen Institute, Seattle, Univ of California system BOARS (Board Of Admissions and Relations with Schools)

Publications:

The clustered gamma protocadherin PcdhγC4 isoform regulates cortical interneuron programmed cell death in the mouse cortex.

Population encoding of stimulus features along the visual hierarchy.

Neurotrophin NT-4/5 Promotes Structural Changes in Neurons of the Developing Visual Cortex.

Activity-dependent recruitment of inhibition and excitation in the awake mammalian cortex during electrical stimulation.

Adolescent oligodendrogenesis and myelination restrict experience-dependent neuronal plasticity in adult visual cortex.

Population encoding of stimulus features along the visual hierarchy.

The Clustered Gamma Protocadherin Pcdh?c4 Isoform Regulates Cortical Interneuron Programmed Cell Death in the Mouse Cortex.

Production of brain-derived neurotrophic factor gates plasticity in developing visual cortex.

Aberrant cortical spine dynamics after concussive injury are reversed by integrated stress response inhibition.

Gamma rhythms and visual information in mouse V1 specifically modulated by somatostatin+ neurons in reticular thalamus.

Chance and Choice: Recollections of a life in science

Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.

Experience-dependent structural plasticity at pre- and postsynaptic sites of layer 2/3 cells in developing visual cortex.

Transplanted cells are essential for the induction but not the expression of cortical plasticity.

Widespread activation of awake mouse cortex by electrical stimulation.

Vesicular GABA transporter is necessary for transplant-induced critical period plasticity in mouse visual cortex.

Flow stimuli reveal ecologically appropriate responses in mouse visual cortex.

Amblyopia: New molecular/pharmacological and environmental approaches.

Development and long-term integration of MGE-lineage cortical interneurons in the heterochronic environment.

Locomotion Enhances Neural Encoding of Visual Stimuli in Mouse V1.

Homeostatic plasticity mechanisms in mouse V1.

Integrating Hebbian and homeostatic plasticity: introduction.

Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions.

Locomotion Induces Stimulus-Specific Response Enhancement in Adult Visual Cortex.

Caudal Ganglionic Eminence Precursor Transplants Disperse and Integrate as Lineage-Specific Interneurons but Do Not Induce Cortical Plasticity.

Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas.

Stochastic Interaction between Neural Activity and Molecular Cues in the Formation of Topographic Maps.

A Neural Circuit That Controls Cortical State, Plasticity, and the Gain of Sensory Responses in Mouse.

Allison Doupe: in memoriam.

A cortical disinhibitory circuit for enhancing adult plasticity.

Cortical plasticity induced by transplantation of embryonic somatostatin or parvalbumin interneurons.

Modeling the dynamic interaction of Hebbian and homeostatic plasticity.

Identification of a brainstem circuit regulating visual cortical state in parallel with locomotion.

Sensory experience during locomotion promotes recovery of function in adult visual cortex.

Interneurons from embryonic development to cell-based therapy.

A cortical circuit for gain control by behavioral state.

1SEP-06 Modeling the dynamical interaction of Hebbian and homeostatic plasticity(1SEP Cooperativity in shaping the nerve cell function,Symposium,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014)).

Development and plasticity of the primary visual cortex.

Dendritic BDNF synthesis is required for late-phase spine maturation and recovery of cortical responses following sensory deprivation.

Harnessing neuroplasticity for clinical applications.

Constitutively active H-ras accelerates multiple forms of plasticity in developing visual cortex.

Genomic imprinting of experience-dependent cortical plasticity by the ubiquitin ligase gene Ube3a.

Cortical plasticity induced by inhibitory neuron transplantation.

Modulation of visual responses by behavioral state in mouse visual cortex.

Neonatal cerebral hypoxia-ischemia impairs plasticity in rat visual cortex.

Retinal input instructs alignment of visual topographic maps.

Reversing neurodevelopmental disorders in adults.

Cortical map formation: Molecular cues and structured neural activity cooperate to organize the topographic map in developing visual cortex.

Roles of ephrin-as and structured activity in the development of functional maps in the superior colliculus.

Delayed plasticity of inhibitory neurons in developing visual cortex.

Distinctive features of adult ocular dominance plasticity.

Highly selective receptive fields in mouse visual cortex.

Tumor necrosis factor-alpha mediates one component of competitive, experience-dependent plasticity in developing visual cortex.

On the importance of static nonlinearity in estimating spatiotemporal neural filters with natural stimuli.

TrkB kinase is required for recovery, but not loss, of cortical responses following monocular deprivation.

Selective disruption of one Cartesian axis of cortical maps and receptive fields by deficiency in ephrin-As and structured activity.

On and off domains of geniculate afferents in cat primary visual cortex.

Intrinsic ON responses of the retinal OFF pathway are suppressed by the ON pathway.

Sleep does not enhance the recovery of deprived eye responses in developing visual cortex.

A combination of ephrin-As and neural activity is required for visual system mapping.

Adaptive filtering enhances information transmission in visual cortex.

Integrated semiconductor optical sensors for chronic, minimally-invasive imaging of brain function.

Development of precise maps in visual cortex requires patterned spontaneous activity in the retina.

Ephrin-as guide the formation of functional maps in the visual cortex.

Ocular dominance plasticity is stably maintained in the absence of alpha calcium calmodulin kinase II (alphaCaMKII) autophosphorylation.

Fine functional organization of auditory cortex revealed by Fourier optical imaging.

Optical imaging of the intrinsic signal as a measure of cortical plasticity in the mouse.

An eye-opening experience.

Molecular substrates of plasticity in the developing visual cortex.

Columnar architecture sculpted by GABA circuits in developing cat visual cortex.

Probing feature selectivity of neurons in primary visual cortex with natural stimuli.

Environmental benefits of implementing alternative energy technologies in developing countries.

New paradigm for optical imaging: temporally encoded maps of intrinsic signal.

Substrates of Rapid Plasticity in Developing Visual Cortex.

Rapid ocular dominance plasticity requires cortical but not geniculate protein synthesis.

The CRE/CREB pathway is transiently expressed in thalamic circuit development and contributes to refinement of retinogeniculate axons.

TrkB-like immunoreactivity is present on geniculocortical afferents in layer IV of kitten primary visual cortex.

Rapid anatomical plasticity of horizontal connections in the developing visual cortex.

Factors shaping the corpus callosum.

Sleep enhances plasticity in the developing visual cortex.

Neuroscience. Drums keep pounding a rhythm in the brain.

Emergence of ocular dominance columns in cat visual cortex by 2 weeks of age.

Infusion of nerve growth factor (NGF) into kitten visual cortex increases immunoreactivity for NGF, NGF receptors, and choline acetyltransferase in basal forebrain without affecting ocular dominance plasticity or column development.

Neurotrophin-4/5 alters responses and blocks the effect of monocular deprivation in cat visual cortex during the critical period.

Spatial frequency maps in cat visual cortex.

Distributions of synaptic vesicle proteins and GAD65 in deprived and nondeprived ocular dominance columns in layer IV of kitten primary visual cortex are unaffected by monocular deprivation.

Cortical degeneration in the absence of neurotrophin signaling: dendritic retraction and neuronal loss after removal of the receptor TrkB.

Rapid extragranular plasticity in the absence of thalamocortical plasticity in the developing primary visual cortex.

Erratum to ‘A method for measuring colocalization of presynaptic markers with anatomically labeled axons using double label immunofluorescence and confocal microscopy’.

A method for measuring colocalization of presynaptic markers with anatomically labeled axons using double label immunofluorescence and confocal microscopy.

Synaptic density in geniculocortical afferents remains constant after monocular deprivation in the cat.

Brain-derived neurotrophic factor overexpression induces precocious critical period in mouse visual cortex.

Hospital merger leaves clinical science intact.

The critical period for ocular dominance plasticity in the Ferret's visual cortex.

Anatomical correlates of functional plasticity in mouse visual cortex.

Sensory maps on the move.

Development and organization of ocular dominance bands in primary visual cortex of the sable ferret.

Selective pruning of more active afferents when cat visual cortex is pharmacologically inhibited.

CRE-mediated gene transcription in neocortical neuronal plasticity during the developmental critical period.

Morphology of single geniculocortical afferents and functional recovery of the visual cortex after reverse monocular deprivation in the kitten.

Local GABA circuit control of experience-dependent plasticity in developing visual cortex.

Effect of sensory disuse on geniculate afferents to cat visual cortex.

Comparison of plasticity in vivo and in vitro in the developing visual cortex of normal and protein kinase A RIbeta-deficient mice.

The role of visual experience in the development of columns in cat visual cortex.

Relationship between the ocular dominance and orientation maps in visual cortex of monocularly deprived cats.

Dendritic development of retinal ganglion cells after prenatal intracranial infusion of tetrodotoxin.

Ocular dominance peaks at pinwheel center singularities of the orientation map in cat visual cortex.

The role of activity in the development of long-range horizontal connections in area 17 of the ferret.

Development of orientation preference maps in ferret primary visual cortex.

Deficient plasticity in the primary visual cortex of alpha-calcium/calmodulin-dependent protein kinase II mutant mice.

Inhibition of nitric oxide synthase does not prevent ocular dominance plasticity in kitten visual cortex.

Plasticity of geniculocortical afferents following brief or prolonged monocular occlusion in the cat.

Experience-dependent plasticity of binocular responses in the primary visual cortex of the mouse.

Ocular dominance plasticity under metabotropic glutamate receptor blockade.

Neuroscience. Growth through learning.

Control of thalamocortical afferent rearrangement by postsynaptic activity in developing visual cortex.

Editorial overview.

COMPLEXITY MAPS REVEAL CLUSTERS IN NEURONAL ARBORIZATIONS.

Precise development from imprecise rules.

Development of orientation selectivity in ferret visual cortex and effects of deprivation.

Development of individual geniculocortical arbors in cat striate cortex and effects of binocular impulse blockade.

Rapid remodeling of axonal arbors in the visual cortex.

Amblyopia induced by anisometropia without shrinkage of ocular dominance columns in human striate cortex.

Neurobiology. Elements of visual perception.

Origin of orientation tuning in the visual cortex.

Neurobiology. Temporal associations.

Seeing the whole picture.

Neuroscience. Cuddling up in the dark.

Relation of cortical cell orientation selectivity to alignment of receptive fields of the geniculocortical afferents that arborize within a single orientation column in ferret visual cortex.

Development of Orientation-Specific Neuronal Responses in Ferret Primary Visual Cortex.

Retinofugal fibres change conduction velocity and diameter between the optic nerve and tract in ferrets.

Experimental and theoretical studies of the organization of afferents to single orientation columns in visual cortex.

Summary: the brain in 1990.

Ocular dominance column development: analysis and simulation.

Visual responses in adult cat visual cortex depend on N-methyl-D-aspartate receptors.

Cortical physiology. Is grandmother an oscillation?

Organization of primary visual cortex (area 17) in the ferret.

Modification of retinal ganglion cell axon morphology by prenatal infusion of tetrodotoxin.

Prenatal tetrodotoxin infusion blocks segregation of retinogeniculate afferents.

Neural plasticity without postsynaptic action potentials: less-active inputs become dominant when kitten visual cortical cells are pharmacologically inhibited.

Segregation of ON and OFF afferents to ferret visual cortex.

Network model of ocular dominance column formation: Analytical results.

Network model of ocular dominance column formation: Computational results.

Anesthetic state does not affect the map of the hand representation within area 3b somatosensory cortex in owl monkey.

Variability in hand surface representations in areas 3b and 1 in adult owl and squirrel monkeys.

Ocular dominance shift in kitten visual cortex caused by imbalance in retinal electrical activity.

Binocular impulse blockade prevents the formation of ocular dominance columns in cat visual cortex.

The effect of analgesic doses of morphine on regional cerebral glucose metabolism in pain-related structures.

Cortical activity blockade prevents ocular dominance plasticity in the kitten visual cortex.

The projection of the visual field onto the lateral geniculate nucleus of the ferret.

Intrinsic projections within visual cortex: evidence for orientation-specific local connections.

Video and scanning microdensitometer-based imaging systems in autoradiographic densitometry.

Somatosensory cortical map changes following digit amputation in adult monkeys.

On and off sublaminae in the lateral geniculate nucleus of the ferret.

Studies of nuclear magnetic resonance imaging and regional cerebral glucose metabolism in acute cerebral ischemia: possible mechanism of opiate antagonist therapeutic activity.

Role of visual afferent activity in the development of ocular dominance columns.

Physiological evidence that the 2-deoxyglucose method reveals orientation columns in cat visual cortex.

With select illustrations created for this book by.

Postnatal development of ocular dominance columns in layer IV of the cat's visual cortex and the effects of monocular deprivation.

Ocular dominance in layer IV of the cat's visual cortex and the effects of monocular deprivation.

Physiological consequences for the cat's visual cortex of effectively restricting early visual experience with oriented contours.

Ocular dominance columns and their development in layer IV of the cat's visual cortex: a quantitative study.

Anatomical demonstration of orientation columns in macaque monkey.

Orientation columns in macaque monkey visual cortex demonstrated by the 2-deoxyglucose autoradiographic technique.

Quantitative study of cortical orientation selectivity in visually inexperienced kitten.

Modification of cortical orientation selectivity in the cat by restricted visual experience: a reexamination.

Eye and head movements evoked by electrical stimulation of monkey superior colliculus.

Response characteristics of single cells in the monkey superior colliculus following ablation or cooling of visual cortex.

Saccadic and disjunctive eye movements in cats.

Single-unit recording and stimulation in superior colliculus of the alert rhesus monkey.