Yadong Huang, MD, PhD

Professor
M_Neurology

Research Description

Research in Huang lab focuses on the causes and progression of Alzheimer’s disease. Specifically, they study a variant of apolipoprotein E, called apolipoprotein E4 (apoE4). Approximately 60–75 percent of Alzheimer’s patients carry the apoE4 variant, making it the most important genetic risk factor for Alzheimer’s disease. The team uses mouse models and induced pluripotent stem (iPS) cells made from skin cells of patients carrying apoE4 or other mutations related to Alzheimer’s to study their effects on the development, survival, and degeneration of neurons and glial cells. In addition, Huang’s lab is working to identify drug targets, develop therapeutic strategies, and repurpose existing drugs for Alzheimer’s disease and other neurodegenerative disorders.

Current Projects

  • Establishing cellular and animal models for Alzheimer's disease research
  • Studying the regulation of apoE expression in neuronal and glial cells in the central nervous system
  • Investigating cell type-specific roles of apoE4 in Alzheimer’s disease and other neurodegenerative disorders
  • Developing therapeutic strategies targeting apoE4’s detrimental effects
  • Repurposing existing drugs for Alzheimer’s disease and other neurodegenerative disorders

Websites

https://gladstone.org/people/yadong-huang#contact

https://labs.gladstone.org/huang/

Academic community service and committee membership: 

Admission committee of Biomedical Sciences Graduate Program
Chair of the Committee for Postdoctoral Fellows and Students at Gladstone Institute of Neurological Disease (GIND)
GIND/UCSF Faculty Search Committee
Gladstone Faculty Promotion Committee
Gladstone Award Selection Committee
Gladstone CIRM Scholarship Admission Committee
National Advisory Council on Aging (NACA), NIH/NIA
Medical Scientific Advisory Council of the Alzheimer's Association of Northern California and Northern Nevada

Publications

Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Kloske CM, Belloy ME, Blue EE, Bowman GR, Carrillo MC, Chen X, Chiba-Falek O, Davis AA, Paolo GD, Garretti F, Gate D, Golden LR, Heinecke JW, Herz J, Huang Y, Iadecola C, Johnson LA, Kanekiyo T, Karch CM, Khvorova A, Koppes-den Hertog SJ, Lamb BT, Lawler PE, Guen YL, Litvinchuk A, Liu CC, Mahinrad S, Marcora E, Marino C, Michaelson DM, Miller JJ, Morganti JM, Narayan PS, Naslavsky MS, Oosthoek M, Ramachandran KV, Ramakrishnan A, Raulin AC, Robert A, Saleh RNM, Sexton C, Shah N, Shue F, Sible IJ, Soranno A, Strickland MR, Tcw J, Thierry M, Tsai LH, Tuckey RA, Ulrich JD, van der Kant R, Wang N, Wellington CL, Weninger SC, Yassine HN, Zhao N, Bu G, Goate AM, Holtzman DM