Yin Shen, PhD
Current Projects
1. Functional genomics (the ENCODE project): high-throughput CRISPR/Cas9 screening of functional regulatory elements. We are using high-throughput CRISPR/Cas9-mediated genetic screening to interrogate the biological significance of a large number of non-coding regulatory sequences in the mammalian genome in both embryonic stem cells and iPSC-derived neural cell types.
2. Charting the regulatory landscape of human brain development and function.
We are utilizing integrative, unbiased, and high-throughput genomic and genetic tools (ATAC-seq, RNA-seq, ChIP-seq, 4C-seq, Hi-C, and CRISPR) to identify and functionally characterize cis-regulatory elements in human brain cells.
3. Investigating the functions of non-coding genetic variation associated with neurological diseases.
Putative regulatory regions harbor a disproportionately large number of sequence variants associated with human traits and diseases, leading to the notion that genetic lesions in the cis-regulatory elements contribute substantially to common human diseases. We are using functional genomics tools to investigate how non-coding variants associated with complex neurological disorders (e.g., autism spectrum disorders (ASD), Alzheimer diseases (AD), and Parkinson disease (PD)) contribute to disease.
Lab Members
Michael Song
Xingjie Ren
Xiaoyu Yang
Kirsty Jamieson
Xiekui Cui
Nicolas Eng
Bingkun Li
Jerry Li
Asami Takagi
Websites