affiliate

Mitochondrial and Metabolic Dysfunction in Neurodegenerative Diseases

Neurobiology of Diseases Affecting Cognitive Function

Areas of investigation
We study processes that result in memory loss and other major neurological deficits, with an emphasis on Alzheimer's disease and related neurodegenerative disorders. Our long-term goal is to advance the understanding of the healthy and the diseased central nervous system to a point where rational strategies can be developed for the prevention and cure of these conditions. 

Looking beyond the neuron: neuroimmune communication, glia, and the extracellular space in brain development and function

Biophysics of Mechanosensation

Understanding Neural Plasticity and Behavior​

Neural Stem Cells and Embryonic Cortical Development

Synaptic Plasticity and Circuit Function in the Basal Ganglia

Neural circuits for homeostatic behaviors

Electrical Signaling at the Mitochondrion in Health and Disease

Neural circuits for emotional behaviors

The primary goal of our research is to delineate the neuronal circuits that underlie emotional behavior so that we may understand how they may be disrupted in mood and anxiety disorders. For this, we use a combination of approaches in mouse models including population calcium imaging, optogenetics, behavior, neural circuit tracing and high-density electrophysiology, in order to control genetically identified brain networks in real time.