Cell chemical biology

Development of covalent chemogenetic K2P channel activators.

Pharmacologic activation of a compensatory integrated stress response kinase promotes mitochondrial remodeling in PERK-deficient cells.

Selective vulnerabilities in the proteostasis network of castration-resistant prostate cancer.

Differential effects of modified batrachotoxins on voltage-gated sodium channel fast and slow inactivation.

Polynuclear Ruthenium Amines Inhibit K2P Channels via a "Finger in the Dam" Mechanism.

Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite.

PINK1-Based Screen Shines Light on Autophagy Enhancers for Parkinson's Disease.