Chemistry & biology

Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens.

Bridging the gaps between synapses, circuits, and behavior.

Bridging the gaps between synapses, circuits, and behavior.

Conformation sensors that distinguish monomeric proteins from oligomers in live cells.

Conformation sensors that distinguish monomeric proteins from oligomers in live cells.

Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs.

Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs.

Beta strand peptidomimetics as potent PDZ domain ligands.

Features of selective kinase inhibitors.

Features of selective kinase inhibitors.

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