Journal of molecular biology

A synthetic peptide initiates Gerstmann-Sträussler-Scheinker (GSS) disease in transgenic mice.

A synthetic peptide initiates Gerstmann-Sträussler-Scheinker (GSS) disease in transgenic mice.

Antibody binding defines a structure for an epitope that participates in the PrPC-->PrPSc conformational change.

Antibody binding defines a structure for an epitope that participates in the PrPC-->PrPSc conformational change.

Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel.

Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel.

Thermodynamics of model prions and its implications for the problem of prion protein folding.

Thermodynamics of model prions and its implications for the problem of prion protein folding.

A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform.

A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform.

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