Nature communications

Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing.

Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins.

GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau.

Structure-guided design of partial agonists at an opioid receptor.

Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility.

Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects.

The commitment of the human cell atlas to humanity.

Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements.

Cilia-enriched oxysterol 7β,27-DHC is required for polycystin ion channel activation.

Inflammatory and neurodegenerative serum protein biomarkers increase sensitivity to detect clinical and radiographic disease activity in multiple sclerosis.

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