Nature methods

Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins.

Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins.

Light-based feedback for controlling intracellular signaling dynamics.

The promise of optogenetics in cell biology: interrogating molecular circuits in space and time.

Chronic optical access through a polished and reinforced thinned skull.

Chronic optical access through a polished and reinforced thinned skull.

Engineering a polarity-sensitive biosensor for time-lapse imaging of apoptotic processes and degeneration.

Engineering a polarity-sensitive biosensor for time-lapse imaging of apoptotic processes and degeneration.

Engineering GPCR signaling pathways with RASSLs.

Two-photon photostimulation and imaging of neural circuits.

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