Proceedings of the National Academy of Sciences of the United States of America

Engaging dystonia networks with subthalamic stimulation.

A mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors.

Nr2f1 enhancers have distinct functions in controlling Nr2f1 expression during cortical development.

Unsupervised pattern identification in spatial gene expression atlas reveals mouse brain regions beyond established ontology.

Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis.

Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins.

Beta and theta oscillations track effort and previous reward in the human basal ganglia and prefrontal cortex during decision making.

Zfp106 binds to G-quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats.

Fibrinogen inhibits sonic hedgehog signaling and impairs neonatal cerebellar development after blood-brain barrier disruption.

TMEM16F exacerbates tau pathology and mediates phosphatidylserine exposure in phospho-tau-burdened neurons.

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