Science advances

Phosphorylation by Aurora kinase A facilitates cortical-cytoplasmic dynamics of Par-3 in asymmetric division of radial glia progenitors.

Aging activates escape of the silent X chromosome in the female mouse hippocampus.

Reinstatement and transformation of memory traces for recognition.

A dynamic in vitro model of Down syndrome neurogenesis with trisomy 21 gene dosage correction.

Encoding of melody in the human auditory cortex.

Optimal trade-off control in machine learning-based library design, with application to adeno-associated virus (AAV) for gene therapy.

Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus.

TMEM106B regulates microglial proliferation and survival in response to demyelination.

Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits.

KLF15 cistromes reveal a hepatocyte pathway governing plasma corticosteroid transport and systemic inflammation.

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