Science advances

Superhuman cell death detection with biomarker-optimized neural networks.

TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy.

The impact of deep space radiation on cognitive performance: From biological sex to biomarkers to countermeasures.

Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath.

Longitudinal tracking of neuronal mitochondria delineates PINK1/Parkin-dependent mechanisms of mitochondrial recycling and degradation.

COUP-TFI specifies the medial entorhinal cortex identity and induces differential cell adhesion to determine the integrity of its boundary with neocortex.

Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division.

The CHD8/CHD7/Kismet family links blood-brain barrier glia and serotonin to ASD-associated sleep defects.

K2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.

A speech envelope landmark for syllable encoding in human superior temporal gyrus.

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