People

John Rubenstein, MD, PhD

Professor

Psychiatry

Genetic Regulation of Forebrain Development

The embryonic neural tube differentiates into diverse structures depending upon their spatial coordinates within the embryo. The forebrain, which is at the rostral end of the neural tube, differentiates into the cerebral cortex, the basal ganglia and other components, each with distinct histologies and functions. Our laboratory is interested in studying the genes that regulate regional specification and differentiation of the mammalian forebrain particularly within the cerebral cortex and basal ganglia.

Philip Sabes, PhD

Professor

Physiology

[email protected]

Cortical mechanisms of sensorimotor integration and learning: measuring and manipulating large-scale neural circuits

Stephan Sanders, PhD

Assistant Professor

Psychiatry

[email protected]

Genomic and bioinformatic approaches to discovering the etiology of neurodevelopmental disorders in humans, especially autism spectrum disorder

Massimo Scanziani, PhD

Professor

Physiology

[email protected]

Christoph Schreiner, MD, PhD

Professor

Vice Chair

Otolaryngology - Head and Neck Surgery

[email protected]

Representation of Complex Signals in the Central Auditory System

Bill Seeley, MD

Professor

Neurology

[email protected]

Selective Vulnerability in Neurodegenerative Disease

My laboratory studies the onset and spread of neurodegenerative disease. We focus on frontotemporal dementia (FTD), a major cause of early age of onset dementia in which most patients develop social-emotional or language dysfunction and progress to death within 5-8 years of diagnosis. We combine clinical and neuroimaging data from living patients with post-mortem pathological observations in the same patients to build more comprehensive models of disease pathogenesis.

Nirao Shah, MD, PhD

Professor

Anatomy

[email protected]

Molecular and Neural Control of Sexually Dimorphic Behaviors

Yin Shen, PhD

Assistant Professor

Neurology

[email protected]

Current Projects

1. Functional genomics (the ENCODE project): high-throughput CRISPR/Cas9 screening of functional regulatory elements. We are using high-throughput CRISPR/Cas9-mediated genetic screening to interrogate the biological significance of a large number of non-coding regulatory sequences in the mammalian genome in both embryonic stem cells and iPSC-derived neural cell types.