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Vesicle Trafficking and Neurotransmitter Release

Mechanisms of Brain Aging and Rejuvenation

Linking Cell Signaling and Membrane Traffic

The overall goal of this laboratory is to identify genetic defects implicated in the onset and progression of multi-factorial metabolic diseases such as obesity and diabetes. Our strategy combines human genetic approaches with molecular biology and animal studies.

Interactions between Neurons and Glia that are Required for the Proper Development and Function of the Nervous System

Reactive Oxygen Species in Neuronal Signaling and Disease

Development and Plasticity of the Central Visual System

Physiology of movement disorders in humans

Genetics and genomics of developmental neuropsychiatric disorders

The State lab focuses on gene discovery in childhood neuropsychiatric and neurodevelopmental disorders and then on leveraging these findings to elaborate underlying pathophysiological mechanisms.

Axon Injury, Disease, and Novel Paradigms for Therapy

Understanding emergent patterns of activity in cortical networks & their relationships to psychiatric disorders